Specialty. Oncology, Dermatology, Breast surgery. Invasive carcinoma of no special type ( invasive carcinoma NST ), invasive breast carcinoma of no special type ( IBC-NST ), invasive ductal carcinoma ( IDC ), infiltrating ductal carcinoma ( IDC) or invasive ductal carcinoma, not otherwise specified ( NOS) is a disease.
Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. Histologically it consists of invasive carcinoma of no special type with In addition, SPC in situ can also be accompanied by invasive disease, which can be in the form of invasive breast carcinoma of no special type or mucinous, tubular, lobular or mixed subtypes [69, 75].

BRCA1-Associated Breast Cancer. Morphologically, BRCA1-associated breast carcinomas are most commonly a high-grade invasive ductal carcinoma of no special type and display minimal if any tubule or glandular formation, markedly pleomorphic nuclei (significant variation in size and shape), vesicular chromatin, prominent nucleoli, and high mitotic activity.

The most common type of invasive breast cancer (more than 75%) is now histologically specified as “no special type,” and called “ductal” carcinomas. Invasive lobular carcinoma is the most prevalent special histologic subtype accounts for about 15% of invasive breast cancers [ 9 ] .
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Breast tumors with neuroendocrine (NE) differentiation comprise an uncommon and heterogeneous group of tumors, including invasive breast cancer of no special type (IBC-NST) with NE features, neuroendocrine tumors (NETs), and neuroendocrine carcinoma (NEC). The most recent World Health Organization (WHO) classification in 2019 defined neuroendocrine neoplasms (NENs) of the breast (Br-NENs) as
The 2012 WHO tumor classification indicates that up to 30% of invasive carcinoma of no special type (NST) shows neuroendocrine differentiation (with any percentage of tumor cells). However, the exact proportion of breast carcinomas with neuroendocrine differentiation is not clear due to lack of studies.
The first patient had a biopsy diagnosis of triple negative invasive carcinoma of no special type of the breast. Sample mix-up with another biopsy was suspected, because in her post-chemotherapy mastectomy specimen, a hormone receptor-positive lobular carcinoma was diagnosed.
Architecturally, most examples of carcinoma with apocrine differentiation resemble invasive breast carcinoma of no special type (NST), with a predominant solid growth pattern. Cytological atypia tends to be moderate or marked with intermediate or high mitotic activity such that these tumours are usually histological grade 2 or 3.
Invasive lobular breast cancer (ILC) is the second most commonly diagnosed type of breast cancer in women, after invasive breast cancer of no special type (NST). ILC accounts for up to 15% of all invasive breast cancers in women. Type A mucinous carcinoma with larger quantities of extracellular mucin represents the classic non-endocrine variety. Pure and mixed variants have been described . The most common admixture is with invasive carcinoma of no special type. A pure tumor must be composed of more than 90% mucinous carcinoma . The in situ component may have a Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. A mixed MBC was defined as two or more metaplastic components. For the 13 mixed MBCs, 4/13 were mixed with squamous cell carcinoma and chondroid/chondroid matrix production; 6/13 were mixed with squamous cell carcinoma, spindle cell type, and invasive carcinoma with no special type; and 3/13 were mixed with squamous cell carcinoma and spindle cell type.
of no special type (NST) comprising the most common invasive breast cancer. We identied 24 MBC cases representing 3.09% of all 766 invasive breast cancers, including 15 cases of pure type and 9
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    • invasive carcinoma of no special type